Selected publications


Recent:

 

  • Elkrief A et al., The negative impact of antibiotics on outcomes in cancer patients treated with immunotherapy: a new independent prognostic factor? Ann Oncol. (2019)
  • Vitale I et al., Macrophages and Metabolism in the Tumor Microenvironment. Cell Metab. 2, 36-50 (2019)
  • Lopez-Otín C et al., Decelerating ageing and biological clocks by autophagy. Nat Rev Mol Cell Biol. 20, 385-386 (2019)
  • Sica V et al., Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate. Cell Rep. 16, 820-834 (2019)
  • Liu et al., Crizotinib-induced immunogenic cell death in non-small cell lung cancer. Nat Commun. 2, 1486 (2019)
  • Madeo F et al., Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential. Cell Metab. 29, 592-610 (2019)
  • Carmona-Gutierrez D et al., The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 19, 651 (2019)
  • Levine B et al., Biological Functions of Autophagy Genes: A Disease Perspective. Cell. 176, 11-42 (2019)
  • Kroemer G et al., Carbotoxicity-Noxious Effects of Carbohydrates. Cell. 175, 605-614 (2018)
  • Obrist F et al., Metabolic vulnerability of cisplatin-resistant cancers. EMBO J. 13, (2018)
  • Gomes-da-Silva LC et al., Photodynamic therapy with redaporfin targets the endoplasmic reticulum and Golgi apparatus. EMBO J. 37, (2018)
  • Routy B et al., The gut microbiota influences anticancer immunosurveillance and general health. Nat Rev Clin Oncol. 15, 382-396 (2018)
  • Zitvogel L et al., The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies. Science. 23 1366-1370 (2018)

 

All-stars:

 

  • Elkrief A et al., The negative impact of antibiotics on outcomes in cancer patients treated with immunotherapy: a new independent prognostic factor? Ann Oncol. (2019)
  • Vitale I et al., Macrophages and Metabolism in the Tumor Microenvironment. Cell Metab. 2, 36-50 (2019)
  • Rao S et al., AIF-regulated oxidative phosphorylation supports lung cancerdevelopment. Cell Res. 29, 579-591 (2019)
  • Carreras-Sureda A et al., Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Nat Cell Biol. 21, 755-767 (2019)
  • Lopez-Otín C et al., Decelerating ageing and biological clocks by autophagy. Nat Rev Mol Cell Biol. 20, 385-386 (2019)
  • Tang D et al., The molecular machinery of regulated cell death. Cell Res. 29, 347-364 (2019)
  • Sica V et al., Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate. Cell Rep. 16, 820-834 (2019)
  • Liu et al., Crizotinib-induced immunogenic cell death in non-small cell lung cancer. Nat Commun. 2, 1486 (2019)
  • Messaoudene M et al., T cell Bispecific Antibodies in Node-Positive Breast Cancer: Novel Therapeutic Avenue for MHC class I Loss Variants. Ann Oncol. 29, (2019)
  • Madeo F et al., Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential. Cell Metab. 29, 592-610 (2019)
  • Polishchuk EV et al., Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis. Gastroenterology. 156, 1173-1189 (2019)
  • Carmona-Gutierrez D et al., The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 19, 651 (2019)
  • Marchi S et al., Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca(2+) levels and tumor growth. EMBO J. 38 (2019)
  • Villella VR et al., A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease. EMBO J. 38 (2019)
  • Levine B et al., Biological Functions of Autophagy Genes: A Disease Perspective. Cell. 176, 11-42 (2019)
  • Bonora M et al., Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles. Nat Rev Cardiol. 16, 33-55 (2019)
  • López-Soto A et al., Cancer-Induced Endoplasmic Reticulum Stress in T Cells Subverts Immunosurveillance. Cell Metab. 28, 803-805 (2018)
  • Galluzzi L et al., Linking cellular stress responses to systemic homeostasis. Nat Rev Mol Cell Biol. 19, 731-745 (2018)
  • Kroemer G et al., Carbotoxicity-Noxious Effects of Carbohydrates. Cell. 175, 605-614 (2018)
  • Boland B et al., Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing. Nat Rev Drug Discov. 17, 660-688 (2018)
  • Bárcena C et al., Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism. Cell Rep. 28, 2392-2403 (2018)
  • Li et al., PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism. Dev Cell. 46, 441-455 (2018)
  • Song X et al., AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System X(c)(-) Activity. Curr Biol. 28, 2388-2399 (2018)
  • Lebeaupin C et al., Bax inhibitor-1 protects from nonalcoholic steatohepatitis by limiting inositol-requiring enzyme 1 alpha signaling in mice. Hepatology. 68, 515-532 (2018)
  • Obrist F et al., Metabolic vulnerability of cisplatin-resistant cancers. EMBO J. 13, (2018)
  • Kang et al., Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis. Cell Host Microbe. 24, 97-108(2018)
  • Gomes-da-Silva LC et al., Photodynamic therapy with redaporfin targets the endoplasmic reticulum and Golgi apparatus. EMBO J. 37, (2018)
  • Routy B et al., The gut microbiota influences anticancer immunosurveillance and general health. Nat Rev Clin Oncol. 15, 382-396 (2018)
  • Song X et al., JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice. Gastroenterology. 154, 1480-1493 (2018)
  • Zitvogel L et al., The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies. Science. 23 1366-1370 (2018)
  • Porporato PE et al., Mitochondrial metabolism and cancer. Cell Res. 28 265-280 (2018)
  • Rybstein MD et al., The autophagic network and cancer. Nat Cell Biol. 20, 243-251 (2018)
  • Pietrocola F et al., Aspirin Recapitulates Features of Caloric Restriction. Cell Rep. 22, 2395-2407 (2018)
  • Abrahão J et al., Tailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere. Nat Commun. 9, 749 (2018)
  • Madeo F et al., Spermidine in health and disease. Science. 26, 6374 (2018)
  • Routy B et al., Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 359, 91-97 (2018)
  • Bantug GR, et al., The spectrum of T cell metabolism in health and disease. Nat Rev Immunol.18, 19-34 (2018)
  • Fridman WH et al., The immune contexture in cancer prognosis and treatment. Nat Rev Clin Oncol. 14, 717-734 (2017)
  • Xie Y et al., Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma. Gastroenterology. 153, 1429-1443 (2017)
  • Jacquelot N et al., Predictors of responses to immune checkpoint blockade in advanced melanoma. Nat Commun. 8, 592 (2017
  • Xie Y, et al., The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. Cell Rep. 20, 1692-1704 2017
  • Zitvogel L et al., Anticancer effects of the microbiome and its products. Nat Rev Microbiol. 15, 465-478 2017
  • Zitvogel L et al., Nutrition, inflammation and cancer. Nat Immunol. 18, 843-850 (2017)
  • Galluzzi L et al., Molecular definitions of autophagy and related processes. EMBO J. 36, 1811-1836 (2017)
  • Galluzzi L et al .,Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat Rev Drug Discov. 16, 487-511 (2017)
  • Esteban-Martínez L et al., Programmed mitophagy is essential for the glycolytic switch during cell differentiation. EMBO J. 36, 1688-1706 (2017)
  • Vitale I et al., DNA Damage in Stem Cells. Mol Cell. 66, 306-319 (2017)
  • L Romani et al., Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis. Nat Med. 23 590-600 (2017)
  • Galluzzi L et al., Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy. Nat Rev Clin Oncol. 14, 247-258 (2017)
  • Galluzzi L et al., Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol. 17, 97-111 (2017)
  • Galluzzi L et al., Necroptosis: Mechanisms and Relevance to Disease. Annu Rev Pathol. 12, 103-130 (2017)
  • Sixt BS et al., The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs. Cell Host Microbe 21, 113-121 (2017)
  • T. Eisenberg et al., Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med 12, 1428-1438 (2016).
  • C. Lopez-Otin, L. Galluzzi, J. M. Freije, F. Madeo, G. Kroemer, Metabolic Control of Longevity. Cell 166, 802-821 (2016).
  • F. Pietrocola et al., Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance. Cancer Cell 30, 147-160 (2016).
  • L. Zitvogel, M. Ayyoub, B. Routy, G. Kroemer, Microbiome and Anticancer Immunosurveillance. Cell 165, 276-287 (2016).
  • L. Galluzzi, A. Buque, O. Kepp, L. Zitvogel, G. Kroemer, Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents. Cancer Cell 28, 690-714 (2015).
  • M. Vetizou et al., Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 350, 1079-1084 (2015).
  • E. Vacchelli et al., Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1. Science 350, 972-978 (2015).
  • G. Kroemer, L. Senovilla, L. Galluzzi, F. Andre, L. Zitvogel, Natural and therapy-induced immunosurveillance in breast cancer. Nat Med 21, 1128-1138 (2015).
  • M. Gentili et al., Transmission of innate immune signaling by packaging of cGAMP in viral particles. Science 349, 1232-1236 (2015).
  • L. Zitvogel, G. Kroemer, CANCER. A p53-regulated immune checkpoint relevant to cancer. Science 349, 476-477 (2015).
  • L. Zitvogel, G. Kroemer, Cancer: Antibodies regulate antitumour immunity. Nature 521, 35-37 (2015).
  • L. Zitvogel, G. Kroemer, CD103+ dendritic cells producing interleukin-12 in anticancer immunosurveillance. Cancer Cell 26, 591-593 (2014).
  • L. Galluzzi, F. Pietrocola, B. Levine, G. Kroemer, Metabolic control of autophagy. Cell 159, 1263-1276 (2014). Sistigu et al., Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Nat Med 20, 1301-1309 (2014).
  • D. R. Green, L. Galluzzi, G. Kroemer, Cell biology. Metabolic control of cell death. Science 345, 1250256 (2014).
  • L. Galluzzi, J. M. Bravo-San Pedro, G. Kroemer, Organelle-specific initiation of cell death. Nat Cell Biol 16, 728-736 (2014).
  • S. Viaud et al., The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science 342, 971-976 (2013).
  • Lopez-Otin, M. A. Blasco, L. Partridge, M. Serrano, G. Kroemer, The hallmarks of aging. Cell 153, 1194-1217 (2013).
  • L. Senovilla et al., An immunosurveillance mechanism controls cancer cell ploidy. Science 337, 1678-1684 (2012).
  • M. Michaud et al., Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science 334, 1573-1577 (2011).
  • L. Zitvogel, G. Kroemer, Anticancer effects of imatinib via immunostimulation. Nat Med 17, 1050-1051 (2011).
  • C. Rubinsztein, G. Marino, G. Kroemer, Autophagy and aging. Cell 146, 682-695 (2011).
  • R. Green, L. Galluzzi, G. Kroemer, Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 333, 1109-1112 (2011).
  • N. F. Delahaye et al., Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nat Med 17, 700-707 (2011).
  • Madeo, N. Tavernarakis, G. Kroemer, Can autophagy promote longevity? Nat Cell Biol 12, 842-846 (2010).
  • L. Zitvogel, G. Kroemer, Targeting dendritic cell metabolism in cancer. Nat Med 16, 858-859 (2010).
  • L. Zitvogel, O. Kepp, G. Kroemer, Decoding cell death signals in inflammation and immunity. Cell 140, 798-804 (2010).
  • T. Eisenberg et al., Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11, 1305-1314 (2009).
  • Ghiringhelli et al., Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med 15, 1170-1178 (2009).
  • D. R. Green, G. Kroemer, Cytoplasmic functions of the tumour suppressor p53. Nature 458, 1127-1130 (2009).
  • L. Galluzzi, G. Kroemer, Necroptosis: a specialized pathway of programmed necrosis. Cell 135, 1161-1163 (2008).
  • Kroemer, J. Pouyssegur, Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 13, 472-482 (2008).
  • E. Tasdemir et al., Regulation of autophagy by cytoplasmic p53. Nat Cell Biol 10, 676-687 (2008).
  • B. Levine, G. Kroemer, Autophagy in the pathogenesis of disease. Cell 132, 27-42 (2008).
  • B. Levine, G. Kroemer, SnapShot: Macroautophagy. Cell 132, 162 e161-162 e163 (2008).
  • J. A. Pospisilik et al., Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell 131, 476-491 (2007).
  • L. Apetoh et al., Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 13, 1050-1059 (2007).
  • L. Galluzzi, G. Kroemer, Mitochondrial apoptosis without VDAC. Nat Cell Biol 9, 487-489 (2007).
  • M. Obeid et al., Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 13, 54-61 (2007).
  • J. Taieb et al., A novel dendritic cell subset involved in tumor immunosurveillance. Nat Med 12, 214-219 (2006).
  • Kroemer, S. J. Martin, Caspase-independent cell death. Nat Med 11, 725-730 (2005).
  • D. R. Green, G. Kroemer, The pathophysiology of mitochondrial cell death. Science 305, 626-629 (2004).
  • L. Perfettini, R. T. Kroemer, G. Kroemer, Fatal liaisons of p53 with Bax and Bak. Nat Cell Biol 6, 386-388 (2004).
  • M. Penninger, G. Kroemer, Mitochondria, AIF and caspases--rivaling for cell death execution. Nat Cell Biol 5, 97-99 (2003).
  • F. Ferri, G. Kroemer, Organelle-specific initiation of cell death pathways. Nat Cell Biol 3, E255-263 (2001).
  • Ravagnan et al., Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol 3, 839-843 (2001).
  • Joza et al., Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature 410, 549-554 (2001).
  • J. M. Bruey et al., Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol 2, 645-652 (2000).
  • C. Brenner, G. Kroemer, Apoptosis. Mitochondria--the death signal integrators. Science 289, 1150-1151 (2000). G. Kroemer, J. C. Reed, Mitochondrial control of cell death. Nat Med 6, 513-519 (2000).
  • K. F. Ferri, G. Kroemer, Control of apoptotic DNA degradation. Nat Cell Biol 2, E63-64 (2000).
  • Zamzami, G. Kroemer, Condensed matter in cell death. Nature 401, 127-128 (1999).
  • S. A. Susin et al., Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397, 441-446 (1999).
  • Marzo et al., Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 281, 2027-2031 (1998).
  • G. Kroemer, The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 3, 614-620 (1997).

Among more than 1000 scientific publications. For a full list please check here.


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among others